There is No Silver Bullet

There is no silver bullet and frankly you probably don’t need one. It is far more important to be able to find the right kind of gun, be able to load the gun, be able to aim the gun, and perhaps most importantly, be able to figure out where the werewolf is.Matthew Oliphant

Vampire Selene uses bullets with silver nitrate to fight off werewolves in "Underworld." Unfortunately, we do not have "silver nitrate bullets" for global health problems.

I always scratch my head a bit when the global health community is dismayed at the revelation that one of its previously hailed “silver bullets” is revealed to not be the miracle cure it was thought to be. The latest disappointment making its way across the blogosphere right now is microfinance: after shady lending practices and harassment of borrowers (driving some to suicide) were uncovered on the part of commercial microlenders in India, the development community began wringing its hands at the unfolding political scandal. The forced retirement of Muhammad Yunus, founder of the Grameen Bank, Nobel laureate, and pioneer of the microfinance institution, looks like the proverbial nail in the coffin of microfinance’s status as the one-stop solution for ending poverty. Now experts are holding panel discussions to debate whether or not microfinance “works.”

This is not the first time we have found ourselves crestfallen at the failure of a silver bullet. When evaluating the results of his “Grand Challenges in Global Health,” Bill Gates admitted that the organization had been “naïve” in its expectations of breakthroughs in vaccine development. He underestimated the time it takes to move new products from the lab through clinical trials and manufacturing. “I thought some would be saving lives by now,” he said, “and it’ll be more like in 10 years from now.” Tell me about it: I worked for a biotechnology start-up in college, and the time it took to get approval for phase I clinical trials allowed bad management to completely unravel the company – it took less than five years. By the time we got the green light from the FDA, the company was being bought out, and we never got to test the product.

Many are also astounded at the current descent from grace of Greg Mortenson, of Three Cups of Tea fame. Details of his inspiring Quixote-esque story of building schools for girls in rural Pakistan and Afghanistan are now being questioned, and donors are appalled at reports of mismanaged funds and schools being used as storage sheds. But don’t we already know that graft happens, and rookies make (sometimes colossal) mistakes? How reasonable was it to expect the Central Asia Institute, Mortenson’s charity, to “fix” Afghanistan by building schools? On the other hand, why are countries and large-scale donors pulling funding and creating a fuss over the graft that the Global Fund revealed through its own investigations?

Why are we continually disillusioned when the simple solutions to the complex problems of global health and poverty turn out to not be so simple? Part of the problem is marketing. Saundra Schimmelpfennig, who has made it her mission to point out and tackle issues surrounding charity (mis)representation and shady fundraising practices, points out that

Whether it’s TOMS A Day Without Shoes or CAI’s Pennies for Peace, schools and teachers are using what are essentially commercials for a charitable product to teach children about the larger world and philanthropy. As is the case with most commercials, these “awareness raising activities” often distort or over-simplify the problems faced in ways that benefit their own organization.

This is extremely worrying as the children brought up on these myths and misconceptions are going to turn into businessmen, philanthropists, and lawmakers. How will the decisions they make be impacted by a distorted view of what the world is like and how to really help?

Another part seems to be that despite each revelation, we are constantly drawn to the prospect that we will somehow still find that magic “something,” that the next innovation or big idea will be the much-sought-after silver bullet. Despite coming to terms with his naiveté, Gates is now saying that energy innovation is the key to beating climate change. Programmers are busily developing cell phone apps in the hope that cell phones can help end poverty.

The problems that we devote our careers to tackling are nowhere near simple, and it is unreasonable to expect to find simple solutions to them. Heck, we don’t even adequately fund the silver bullets we already have. As professionals more knowledgeable than me continually point out, our best bet is to strengthen health systems, focus on measurable improvements, admit and learn from failure, and – perhaps most importantly – have a little patience.

The Greatest Thing You’ll Ever Learn: Drug-Resistant Tuberculosis on the Rise

On most days, tuberculosis only crosses the average American’s awareness radar when he or she is watching Moulin Rouge! for the fifth time. Even then, the sight of the courtesan Satine (played by Nicole Kidman) coughing up blood after singing about diamonds gives the impression that TB is the problem of sex workers living in elephants in 19th-century France. All of this changed in 2007, when Georgia lawyer Andrew Speaker snuck back into the U.S. through Canada after honeymooning in Europe – and being diagnosed with extensively-drug-resistant tuberculosis (XDR-TB).

As if regular TB were not bad enough, global health professionals are now grappling with the rising incidence of multi-drug-resistant (MDR-TB) and extensively-drug-resistant (XDR-TB) tuberculosis. MDR-TB is resistant at least to isoniazid and rifampicin, the two most powerful first-line antibiotics used to treat TB. It typically develops when patients being treated for fully sensitive TB stop their treatment course or do not follow it regularly (either because they feel better or forget to take their drugs, or because treatment supplies run out). When the treatment is interrupted before all of the bacteria are killed, the microbes develop resistance to the drugs. XDR-TB has all of this and more: it is also resistant to any fluoroquinolone and at least one of three injectable second-line drugs (capreomycin, kanamycin, and amikacin). If these drugs sound scary, it is because they are: most second-line drugs are less effective than isoniazid and rifampicin and can be moderately to highly toxic.

While the incidence of drug-resistant strains of TB is low for the moment, it is on the rise: a recent report by the WHO found that over two million people will contract some form of drug-resistant TB by 2015. The frequency of these infections is increasing fastest in India, China, and the former USSR. The WHO is asking countries to put their money where their mouths are and step up to fight the disease. “Commitments by some countries are too slow off the mark or simply stalled,” said Rifat Atun, director of strategy, performance and evaluation at the Global Fund. In the meantime, the greatest thing you’ll ever learn…is to finish your antibiotic course.

The Danger in Overlooking Environmental and Occupational Health

A black-and-white photo of a gold mine in the 19th century.
Flickr, U.S. National Archives

I often get quizzical looks from public health professionals when, after explaining that I am interested in international health, I tell them that I got my MPH in Environmental Health. For example, while riding the shuttle from the airport to the Convention Center for the APHA Annual Meeting this past November, I struck up a conversation with an Environmental Health professor. She seemed puzzled when I told her that I was a member of the International Health section and then explained that my MPH focus (and my current job) was in environmental and occupational health. She then (very politely) invited me to the Environmental Health Section’s social hour.

While I certainly appreciated the invitation, I remain puzzled (and slightly frustrated) that there is relatively little discussion of environmental and occupational health issues in international health. The field is dominated by discussion of the Big Three diseases (HIV/AIDS, malaria, and TB), sanitation, tropical worms, MCNH issues, malnourishment, and poverty. While these are all very important issues deserving of attention and funding, EOH should by no means be left out: after all, every human being is affected by the environment around him or her, and nearly all of us hold some kind of occupation to put food on the table.

One story in particular caught my eye a few weeks ago. Nearly 300 children in Zamfara state in northern Nigeria have died from lead poisoning due to mining activity over the last two years; another 742 are currently being treated for high blood lead levels. Lead poisoning fall squarely under environmental health – my cubicle neighbor is a nurse for the Texas Childhood Lead Poisoning Prevention Program – but this story had all of the trappings of a “classic” IH scenario: poor people in small villages in a developing country, Doctors without Borders, and sick African babies.

Mining is a significant issue, and a heated debate, in the field of development. Proponents of mining include the World Bank, which maintains that mining provides jobs, government revenues, and local economic benefits, and that it can provide sustainable development to communities with appropriate regulation. Critics argue that the pollution and environmental damage generated by mining operations outweigh the benefits, that it exploits local communities, and that the revenues are largely kept by local elites and foreign shareholders. And we all know that resources are too often followed by bloody conflict: civil wars in Sierra Leone, Angola, and Liberia, and armed conflict in the DRC, are just a few examples that come to mind. There are a number of health ramifications as well: constant exposure to rock dust makes miners more susceptible to tuberculosis, which they can spread to their families. Artisanal gold mining in particular, which supplies at least one fourth of the world’s total gold supply, is one of the most significant sources of the release of mercury into the environment.

Despite the hazards and health risks, however, the issue gets relatively little attention compared to the traditional global health villains of sanitation and infectious disease. This is unfortunate because all of the same factors play into mining in impoverished communities: residents and farmers take up mining and mineral extraction to improve their livelihoods because it pays better and provides more security than subsistence farming. There are issues of sustainability, ownership, exploitation, and corruption. Somit Varma, director of the Oil, Gas, Mining & Chemicals Department of the World Bank/IFC, has said that “the social and economic characteristics of small-scale mining fully reflect the challenges of the Millennium Development Goals, including: health, environment, gender, education, child labour, and poverty eradication.”

Advocates are becoming more vocal in drawing attention to “non-typical” international health issues, including cancer and mental illness. We should add environmental and occupational health issues to that list as well. While these issues are inevitably more complicated to prevent, screen for, and treat than the Big Three or NTDs – after all, you can’t pass out condoms or implement DOTS for lead poisoning or silicosis – they still impact the world in a major and often devastating way and are still deserving of our attention.

I will not be blogging about AIDS today: World AIDS Day Round-Up

Flickr, Sully Pixel

Today is World AIDS Day, which means that every blog out there that deals with international health, development, and/or humanitarian work has commented on it in some form or fashion. (I have seen great material on Humanosphere in particular.) Since most of these people are well-established professionals that know way more than I do, I will let them all speak for me and just try to collect the highlights of all that I have read today.

The Global Health Delivery Project put together a great round-up of media stories and major research reports.

End the Neglect posted a reading list as well as a great “status report” by blogger Alanna Shaikh.

The Center for Global Development has posted several blog entries on HIV/AIDS leading up to today, including a response to President George W. Bush’s piece on Pepfar in the Washington Post.

And finally, my personal favorite: Sarah Boseley of the Guardian wrote a piece on the importance of keeping AIDS on the agenda all year long.

One Step Forward, Two Steps Back: Court Decision in China Upholds HIV Employment Discrimination

China always seems to find its way into human rights headlines these days. Now that the sound and fury of Liu Xiaobo’s Nobel Peace Prize has died down, the People’s Republic is in the news again: this time for a landmark court decision in which a man lost a discrimination case for being denied a teaching job based on his HIV status. Wu Xiao (an alias that means “Little Wu”), a 22-year-old college grad, passed a series of written tests and an interview for the position, so he should have been perfectly qualified for the post. However, when his mandatory blood test revealed his HIV status, the local education bureau in Anqing rejected his application. The court ruled that the criteria for hiring civil servants (which disqualifies HIV-positive individuals from being hired) overrules a 2006 law that prohibits discrimination against persons with HIV and their families. The verdict is highly discouraging to Chinese AIDS advocates.

Discrimination against persons with HIV is nothing new. The history of the disease is littered with horror stories of stigma, persecution, and invasion of privacy, and discrimination continues all over the world in various forms, including cultural norms and, in some cases, even laws. In Chile, HIV-positive women are frequently pressured to get sterilized, and some are even sterilized without consent. Twenty-two countries, including Russia, Egypt, and South Korea, will deport foreign nationals based solely on HIV status, and other countries (such as Malaysia and Syria) will not allow students with HIV to apply for study. Gugu Dlamini, a SouthAfrican woman, was beaten to death after speaking openly about her HIV status at an AIDS awareness gathering on World AIDS Day in 1998.

China is certainly no stranger to HIV/AIDS discrimination. From the government’s frantic cover-up of the “Bloodhead Scandal” (in which 30,000-50,000 people were infected through blood transfusion programs in the 90s) to present-day violations of patient privacy laws, Chinese HIV patients face harsh stigma from healthcare providers, government officials, and their friends and neighbors. On the surface, the country has been somewhat proactive in mitigating this: it passed its first laws regarding HIV patient privacy in 1988, and it is illegal to disclose personal information of HIV-positive individuals. Chinese President Hu Jintao and Prime Minister Wen Jiabao make visible appearances with people with AIDS every year on World AIDS Day, and ARVs are available to AIDS patients for free. However, privacy laws are routinely violated, and people with HIV are ostracized from their families and communities. The government routinely harasses and often imprisons AIDS activists (Hu Jia, for example, was held under house in 2006 and has been in jail since 2008). Fear, ignorance and the threat of discrimination discourage individuals from getting tested and deter many who already know their status from seeking treatment. Chinese AIDS patients are encouraged by their providers to use fake names and IDs when seeking treatment and picking up medicines.

Wu’s lawyers plan to appeal the decision, but advocates are frustrated. “The entire H.I.V. community had high hopes, but now the door appears to be shutting for people who want to use the courts to fight against discrimination,” said Yu Fangqiang, whose organization represented Wu in his case. Others, however, urge patience, and point out that the fact that the case was even heard demonstrates progress. Either way, it is crucial to end the institutionalization of discrimination against HIV. Cultural norms will not change until the official government position changes, and, along with it, its laws. People will not seek treatment until they are no longer afraid to come out of hiding.