Innovative Malaria Research in Southeast Asia: a UCI GHREAT Initiative (Video Review)

by Niniola Soleye

The University of California, Irvine (UC Irvine) recently released the first video in their four-part series showcasing the success of their Global Health Research, Education and Translation (GHREAT) Initiative. The initiative is headed by IH section member Dr. Brandon Brown. The goal of the video series is to demonstrate how GHREAT projects are enhancing health and saving lives all over the world. This first video was shot in Thailand and focuses on malaria research in Southeast Asia.

Myanmar has the largest number of malaria cases in Asia. Due to the poor economic conditions in the country, people immigrate to neighboring countries, including Thailand, to look for employment opportunities. Additionally, there has been an increase in drug-resistant malaria and an influx of counterfeit drugs. That, coupled with poverty and people not having funds to travel to the hospital or buy medicine, has resulted in malaria becoming a major public health problem in the region.

UC Irvine faculty, staff, and students partnered with the ministry of health, hospital workers, local health workers, and academic researchers in China, Myanmar, and Thailand to study malaria control in the border regions, and develop solutions for containing the malaria outbreak.

The video shows the UC Irvine team observing local health workers as they perform diagnostic blood-tests for malaria in Thai villages. Their observations led them to focus their efforts for this project on developing an innovative, non-invasive diagnostic test using saliva instead of blood.

Untreated, malaria can lead to death two to three weeks after infection, so early diagnosis and treatment are key. Blood testing requires workers to send samples away daily, delaying the start of treatment. Using saliva would allow for a fast, portable, low-cost diagnostic tool, all critical factors in a developing country setting.

One scene that stood out showed a young child getting tested for malaria. She was crying because she didn’t want to get her finger pricked, and also because she was afraid of the health worker. In situations like that, the new test would be quite beneficial.

Overall, the video does a good job of emphasizing how direct, firsthand experiences and observations are important when trying to innovate and solve problems in global health. I would have liked to hear more about the technique behind the saliva test, their border control efforts, how they plan to deal with the counterfeit drug problem, and how they’ll address drug-resistant malaria but the video doesn’t go into detail on those topics.

Click here to watch the video.

Global Health Weekly News Round-Up

Politics and Policies:

  • The Food and Drug Administration has announced that it will begin exercising its authority given under a 2009 law, power to regulate cigarettes and other tobacco products that they believe pose public health risks.
  • In an effort intensify campaign to publicize new health insurance options and to persuade consumers, the White House is recruiting mayors, county commissioners and other local officials.

Programs:

  • A health check program has been launched in Accra, in order to reach out to the people of Ghana who are challenged with non-communicable diseases (NCDS), in an affordable and effective way.
  • The United Kingdom (UK) is starting a rotavirus vaccination program to protect the babies from infection which causes diarrhea, vomiting, abdominal pain, fever and dehydration.
  • Ben & Catherine Ivy foundation grants more that $9 million for brain cancer research.

Research:

  • To help avert 3 million AIDS deaths by 2025, the World Health Organization (WHO) through its guidelines is recommending the patients the start medicine at earlier stage of the deadly disease.
  • According to global Diabetes attitudes, wishes and needs 2 study one in five people with diabetes feel discriminated against them because of their condition. About 16% people suffering from this condition are at risk of depression.
  • According to the United Nations Program on HIV/AIDS (UNAIDS), Ghana cuts new HIV infections among children by 76% since 2009. It states that one three in ten children in need of treatment have access to it.
  • A report released by the United Nations state that Nigeria has highest number of children with HIV/AIDS virus in the world. It states that the incidence rate has not increased much but the increase in the prevalence rate has remained stagnant.
  • According to the scientists, new World Health Organization (WHO) test- based approach against malaria does not work everywhere. There must be a hard diagnosis before the disease is treated.
  • According to the research results published in the Journal of Infectious diseases, infant rotavirus vaccine is effective against this disease in Ghana. Results showed a significant response in parameters of efficacy, safety and immune impact of vaccine.
  • A study published in the journal’ Diabetologia’, ethnicity should be considered while making guidelines for physical activity. They state that south Asians need more exercise than white Europeans to reduce diabetes risk.
  • According to a research review published in BMJ, high consumption of fish reduces risk of breast cancer by 14%. It replenishes the body with all omega 3 essential fatty acids which can only be acquired from external sources as body cannot manufacture it.
  •  In a study published in Cell Transplantation journal, type 2 diabetes patients who receive self-donated bone marrow stem cells require less insulin. According to the scientist’s good glycemic control appeared as a critical factor in the transplanted and non-transplanted control group.
  • A study indicates that consuming more than 2-3 standard alcohol drinks per day is linked to deadly digestive tract cancers including mouth, throat, larynx and esophageal. They also warn of risk of bowel, breast and prostate cancers.
  • The scientists have found out that the patients of Crohn’s disease also have a virus – enterovirus in their intestines as compared to those who did not have this disease. It also said that the genes associated with the onset of this disease are vital for the immune response against this virus.
  • According to the researcher’s malaria parasite are full of iron which they cannot digest nor can excrete them. Their invention- hand-held battery operated malaria detector will use the power of magnets to detect them.

Diseases & Disasters:

  • Reports state that Lusaka (Zambia) records approximately 185 new HIV/ AIDS infections every day. It has high prevalence rate of 20.8 percent as compared to the other districts of Zambia.
  • The cholera epidemic in the Democratic Republic of the Congo claims lives of 257 people. Lack of proper sanitation and clear water are stated to be the main cause of the outbreak.
  • Polio outbreak in Somalia jeopardizes global eradication. Before this there was no case of this disease for more than five years. This outbreak is reported in its early stages and WHO experts see more cases coming in next few weeks.
  • A report released by Greenpeace suggests that a Chinese herbal medicine contains a variety of pesticides. It is increasingly accepted in the western countries for medicinal use.
  • Reports have shown a new trend of HIV infection among the youths of Manipur (India). Unsafe sex practice has been indicated to be the major mode of HIV transmission among them.
  • According to the UK’s Medicines and Healthcare Products Regulatory Agency (MHRA). Diclofenac, a common painkiller raises the risk of heart attack and stroke among the patients with serious underlying heart conditions.
  • Health officials are warning that tularemia cases are on rise in New Mexico. Four cases have been so far been reported.
  • Japan and Poland are facing epidemic of rubella. Travel warnings have been issued by the Centers for Disease Control and Prevention for the pregnant females visiting these countries.

IH News Global Health Weekly News Round-Up

  • May 31 was observed as World anti-tobacco day by the World Health Organization.
  • The Fitness Industry Council Canada has announced June 1 as National Health and Fitness Day.

Politics and Policies:

  • The Republic of Congo has passed a law that prohibits the purchase, consumption and possession of tobacco for minors, pregnant women and mentally ill. The advising and any kind of promotion of tobacco are also prohibited in the country. Smoking is prohibited in public places.
  • According to the World Health Organization On June 10th Ethiopia is launching an emergency mass-vaccination campaign against yellow fever.
  • According to the Ghana’s Minister of Health, the country is committed to ban all forms of tobacco advertisements and promotions.
  • Smoking in presence of children equaled to physical violence in Latvia.
  • Russia’s smoking ban came into effect on Saturday. It involves no smoking in public places and curbing cigarette advertising and sales.

Programs:

  • The World Health Organization (WHO) in Gambia is launching polio campaign to vaccinate 400,000 children under five years.
  • The Ministry of Finance of Lesotho has signed two agreements totaling $17 million with the Global Fund to fight against HIV/AIDS, tuberculosis and malaria.
  • Professionals for Humanity International (PROFOH) have announced its third free medical screening in this year in Nigeria.
  • After the discovery of polio this week, United Nations emergency team rushes to vaccinate 424,000 people living in a refugee camp in Kenya.
  • Zimbabwe is going to conduct its first national tuberculosis prevalence survey with an objective to determine the national prevalence of bacteriologically-confirmed pulmonary TB among people aged 15 and over.
  • Rotary India extends its help to Pakistan in its polio vaccination drive.
  • The World Health Organization is calling on the countries to ban advertising about the tobacco products.

 Research:

  • Improvement of maternal health and reduction in child mortality in some countries was highlighted in a recently released report ‘Accountability for Maternal, newborn and Child Survival ‘.
  • According to the director of the National Institute of Combat of HIV (INLS), the prevalence of HIV in Angola has not changed since 1997.
  • According to the researchers patients who have developed oral cancer due to HPV can have sex with their spouses or long term partners.
  • According to a study done by the researchers at the Institute for Clinical Evaluative Sciences, rates of diabetes have jumped 15 fold within a decade for the Chinese Canadians.
  • A systemic review confirms that the licensed medicines for smoking cessation are successful in assisting people to quit smoking.
  • Scientists are using new optics-based single virus detecting methods for determining the exact viral load of a sample by counting individual virus sample.
  • New malaria vaccine developed by the team Japanese researchers has cut the infection rates by 72%.
  • A study conducted in over 13 hospitals in Indonesia, Singapore, Thailand and Vietnam shows that doubling Tamiflu vaccine dose does not help in severe flu.
  • Results of a study warn development of resistance to drug used in treatment of H7N9 virus.
  • A group of scientists discover how a single gene mutation helps brain cancer cells to survive and drive tumor growth.
  • According to the United Nations scientists, Fukushima No.1 nuclear plant has very low radiation doses and there is no increased risk of cancer on local residents.
  • According to the experts nearly one-sixth of young adults in Sri Lanka are overweight. Lack of nutrition education and food culture of the country are reasons for this problem.
  • A study states that particular combination of bacteria in the human digestive system can identify patients who have or are likely to develop Type 2 diabetes.
  • A study shows that the Coenzyme Q10 cuts the mortality rate by half in heart failure patients.
  • Report released by EU says that several new health risks are emerging from new chemicals, products and changing lifestyle patterns. It is important to address these issues all together.
  • According to a study fizzy drinks do harm to the teeth as drugs.
  • New vaccine for lung cancer has been developed by the scientists of Argentina and Cuba. It activates the body’s immune system to promote its destruction.

Diseases & Disasters:

  • Tornadoes hit Oklahoma again on 1st June. Death toll rises to 9.
  • A report issued by the Chinese Ministry of Land and Resources state that the ground water of China is poisoned. It did not address the severity and scope of this problem.
  • Death toll from bird flu has risen to 38 in China.
  • According to the reports of the United Nations, there is a suspected outbreak of Ebola fever in the north of the Democratic Republic of Congo.
  • According to the reports by Ghana Health Service, cholera outbreak hits greater Accra region.
  • The World Health Organization is concerned about the new strain of Coronavirus which has killed 55 of the confirmed cases.
  • A Starbucks in Hong Kong used water from the public restroom to brew coffee.
  • Pakistan is facing a severe measles epidemic. Since the start of 2013 about 239 deaths have been reported.
  • According to the Ministry of Health, Philippines, new cases of HIV infections recorded in the month of April were 388. It was 67 percent higher than those recorded in April 2012.
  • According to the reports Singapore is facing Dengue epidemic. More than 7,700 people are reported to be infected as of May 25.
  • Frozen berry and pomegranate mix has been reported to be linked to hepatitis A outbreak in five states in U.S.

IH News Global Health Weekly News Round-Up

  • First UN International Day of fistula marked in Ghana to ensure that victims were treated and re-integrated into society in Ghana.

Politics and Policies:

  • The government of Mauritius is preparing to enforce new laws for more graphic warnings on cigarette packs.
  • Voters in Portland have defeated measures to add fluoride to water supply.
  • The Texas House passed a measure that would prevent the state from expanding its Medicaid program.
  • Abortion Law (procedure at the 12th week of pregnancy) in Arkansas is temporarily blocked by a federal judge.

Programs:

  • The World Bank has announced $1 billion in a proposed new funding to help countries in the Africa’s Great Lakes Region to provide better health and education services besides targeting energy, roads, agriculture, cross-border trade and jobs.
  • United Nations Family Planning Innovation to launch two new initiatives that will increase access to family planning and improve maternal health in the world’s most marginalized areas.
  • The Business of a Better World (BSR) has launched an online platform to create culturally accurate training materials on women’s health in developing countries.
  • GlaxoSmithKline (GSK) has announced its contribution of $750,000 to the One Million Community Health Workers Campaign in sub-Sahara Africa.
  • Power to childcare centers ban unvaccinated children in Queensland.
  • An independent organization, Save the Children has received a contribution of $500,000 to support its ongoing flood relief efforts in Mozambique.
  • An emergency preparedness ad response center is being launched by the experts from the United Nations International Atomic Energy Agency (IAEA) in Fukushima, Japan.
  • United Nations refugee agency is working to help to contain cholera epidemic in Niger by implementing emergency sanitation and prevention measures.
  • UNICEF is working to prevent further spread of measles in the Central African Republic.
  • Mass vaccination campaign contained the spread of meningitis in South Sudan. The meningitis outbreak was declared by the ministry of health on April 30.

 Research:

  • According to the reports the World Health Organization has applauded Eritrea on its accomplishments in combating malaria.
  • Most EU beaches get clean bill of health, by the European Environment Agency. It says vast majority are clean and safe.
  • According to a new study relaxation of marijuana laws in Colorado has caused significant spike in number of young children treated for accidentally eating marijuana-laced cookies, candies, brownies and beverages.
  • A report by Substance Abuse and Mental Health Services Administration (SAMHSA) says that one in ten parents did not talk to their teen children about dangers of consuming drugs, alcohol etc.
  • In the 66th World Health Assembly, the WHO has praised Thailand for the world’s best governance for medicine.
  • According to the United Nations Report, the number of people in Africa receiving antiretroviral treatment has increased from less than 1 million to 7.1 million over the seven years.
  • According to a report released by the United Nations Japan must continue efforts to deactivate Fukushima nuclear plant.
  • In a report released by the United Nations greater efforts and more resources are needed to improve health of Palestinian refugees.
  • A study shows that potatoes and beans provide most nutrients per penny.
  • According to a study conducted by Dr. Bassiouny at Kornberg School of Dentistry, diet soda might be as bad for teeth health as taking methamphetamines or crack cocaine.
  • According to a study published in The Journal of Alzheimer’s Disease, two compounds found in cinnamon can play a role in delaying the onset of Alzheimer’s disease.
  • A research presented at the Heart Failure Congress 2013, heart failure accelerates the aging process and brings on early andropausal syndrome (AS).
  • The scientists at the Massachusetts Institute of Technology (MIT) have developed an injectable nanogel that can monitor blood-sugar levels and secrete insulin when treated.
  • A study revealed that the people who were interviewed while eating at fast food restaurants typically underestimate the calorie count of the meal in front of them by a large margin.

Diseases & Disasters:

  • A category EF-5 storm killed 24 people, injured many and damaged and estimated 12,000 homes in Moore, Oklahoma on May 20.
  • A parliamentary committee has revealed that since last year in Zimbabwe, more than 45,000 people have died due to HIV-related ailments and around 1.2 million people are living with this virus.
  • Disease kills children, causes miscarriages in camps near Nyala, South Darfur.
  • According to Tunisia Ministry of Health, SARS- like virus is being reported spreading among the people of country.

IH News Global Health Weekly News Round-Up

  • The Ministry of Health and Social Welfare (Gambia) in collaboration with WHO UNICEF, Rotary International and other partners  observe  the week of May 2013 (from 24- 27) as National Immunization (NIDs) days against poliomyelitis.
  • May is skin Cancer Awareness Month.
  • May 19 was observed as National Asian & Pacific Islander HIV/AIDS Awareness Day.

Politics and Policies:

  • Kenya is the first country to protect girls against cervical cancer with GAVI- supported human papillomavirus (HPV) vaccines.
  • The government of Canada has announced its support in the fight against tuberculosis, malaria and HIV/AIDS.
  • India’s health ministry is tying itself in knots over the ban of drugs that are banned in some countries and some cases for some population segments.
  • The Illinois Senate has voted to approve the use of marijuana for medical purposes.

Programs:

  • Zambia- Zimbabwe Cross Border Malaria Initiative, a joint co-ordination launched by Zambia and Zimbabwe to control malaria and accelerate reduction of its transmission among the border communities.
  • Merck and Glaxo cut price of Human Papilloma Virus drug in the poorest countries. This cut is more than 95%.
  • Nigeria seeks support on guinea worm eradication.
  • Ghana Health Service has launched the country’s first online based health service which allows patients to engage with doctors online over minor ailments.
  • The Gambia and the World Health Organization (WHO) has launched a Comprehensive Tobacco Control formulation in Bakau.
  • India develops cheap vaccine (against Rotavirus) against major cause of diarrhea deaths in children.
  • The Child Division at the Ministry of Health and Population (MoHP) is working to introduce pneumococcal vaccine against pneumonia– major cause of death among children less than five years of age in the country.

 Research:

  • According to Cervical Cancer Crisis card that used data from official reports by the World Health Organization, Africa has the highest cervical cancer deaths.
  • According to the 2011 National HIV Indicator Survey, prevalence rates among the Ugandans between ages of 15 to 19 are rising.
  • The Annual State of the World’s Mothers report states that every year three million babies die within the first month of life.
  • A study published shows that HIV prevalence and late diagnosis of HIV infection is high among young women with sexual risk behavior in Beira, Mozambique.
  • According to a Global Mother’s Wellbeings ranking report, Ghana ranks 146th out of 176 countries.
  • According to the Maternal and Neonatal Tetanus Elimination Initiative partners, landmark has reached in fight against tetanus. It has been eliminated in over half of 59 priority countries.
  • According to a study, number of Australian parents with mental illness has increased by 3% every year from 1990 to 2005.
  • The findings of a study published in the World Allergy Organization Journal, children dwelling in commercial areas of New Delhi, India are most susceptible as compared to those living in other parts of the capital, to the respiratory ailments followed by industrial and residential areas.
  • A study shows that the paradoxical TB-IRIS frequently complicates HIV-TB therapy in India.
  • A paper published in The Lancet Oncology, say that if current trends in cancer among the people of Latin America and Caribbean continue, the region will see cancer cases soaring by third each year to reach 16.8 million in total by 2020.
  • According to a study health of the immigrants suffer as they live longer in the U.S.
  • According to a study, newer whooping cough vaccine is as protective as was thought to be.

Diseases & Disasters:

  • According to the reports Zambia is facing shortage of HIV medicines.
  • Heavy rains have caused flooding of both Nyamamba and Nyamugasani rivers in Uganda. It has caused heavy flooding which has displaced thousands of people.
  • Two cases of wild polio virus have been recorded in Tafa Local government area of Niger and Fagge in Kano respectively in Nigeria.
  • Reports have indicated that African mineworkers are at significant risk of becoming resistant to tuberculosis treatment.
  • Body of a man who died in an unnamed hospital as having suffered from Creutzfeld –Jakob disease has been identified by the L. Greenberg Forensic Institute at Abu Kabir.  According to the Health Ministry danger of being infected under normal conditions are negligible.
  • A travel alert has been issued for dengue fever in Thailand. About 33 deaths have been reported since April of this year, particularly in northeastern part of the country.
  • According to the reports more than 1200 new cases of measles have been reported this year. Health officials are scrambling to catch up and stop a growing this growing epidemic.