There is No Silver Bullet

There is no silver bullet and frankly you probably don’t need one. It is far more important to be able to find the right kind of gun, be able to load the gun, be able to aim the gun, and perhaps most importantly, be able to figure out where the werewolf is.Matthew Oliphant

Vampire Selene uses bullets with silver nitrate to fight off werewolves in "Underworld." Unfortunately, we do not have "silver nitrate bullets" for global health problems.

I always scratch my head a bit when the global health community is dismayed at the revelation that one of its previously hailed “silver bullets” is revealed to not be the miracle cure it was thought to be. The latest disappointment making its way across the blogosphere right now is microfinance: after shady lending practices and harassment of borrowers (driving some to suicide) were uncovered on the part of commercial microlenders in India, the development community began wringing its hands at the unfolding political scandal. The forced retirement of Muhammad Yunus, founder of the Grameen Bank, Nobel laureate, and pioneer of the microfinance institution, looks like the proverbial nail in the coffin of microfinance’s status as the one-stop solution for ending poverty. Now experts are holding panel discussions to debate whether or not microfinance “works.”

This is not the first time we have found ourselves crestfallen at the failure of a silver bullet. When evaluating the results of his “Grand Challenges in Global Health,” Bill Gates admitted that the organization had been “naïve” in its expectations of breakthroughs in vaccine development. He underestimated the time it takes to move new products from the lab through clinical trials and manufacturing. “I thought some would be saving lives by now,” he said, “and it’ll be more like in 10 years from now.” Tell me about it: I worked for a biotechnology start-up in college, and the time it took to get approval for phase I clinical trials allowed bad management to completely unravel the company – it took less than five years. By the time we got the green light from the FDA, the company was being bought out, and we never got to test the product.

Many are also astounded at the current descent from grace of Greg Mortenson, of Three Cups of Tea fame. Details of his inspiring Quixote-esque story of building schools for girls in rural Pakistan and Afghanistan are now being questioned, and donors are appalled at reports of mismanaged funds and schools being used as storage sheds. But don’t we already know that graft happens, and rookies make (sometimes colossal) mistakes? How reasonable was it to expect the Central Asia Institute, Mortenson’s charity, to “fix” Afghanistan by building schools? On the other hand, why are countries and large-scale donors pulling funding and creating a fuss over the graft that the Global Fund revealed through its own investigations?

Why are we continually disillusioned when the simple solutions to the complex problems of global health and poverty turn out to not be so simple? Part of the problem is marketing. Saundra Schimmelpfennig, who has made it her mission to point out and tackle issues surrounding charity (mis)representation and shady fundraising practices, points out that

Whether it’s TOMS A Day Without Shoes or CAI’s Pennies for Peace, schools and teachers are using what are essentially commercials for a charitable product to teach children about the larger world and philanthropy. As is the case with most commercials, these “awareness raising activities” often distort or over-simplify the problems faced in ways that benefit their own organization.

This is extremely worrying as the children brought up on these myths and misconceptions are going to turn into businessmen, philanthropists, and lawmakers. How will the decisions they make be impacted by a distorted view of what the world is like and how to really help?

Another part seems to be that despite each revelation, we are constantly drawn to the prospect that we will somehow still find that magic “something,” that the next innovation or big idea will be the much-sought-after silver bullet. Despite coming to terms with his naiveté, Gates is now saying that energy innovation is the key to beating climate change. Programmers are busily developing cell phone apps in the hope that cell phones can help end poverty.

The problems that we devote our careers to tackling are nowhere near simple, and it is unreasonable to expect to find simple solutions to them. Heck, we don’t even adequately fund the silver bullets we already have. As professionals more knowledgeable than me continually point out, our best bet is to strengthen health systems, focus on measurable improvements, admit and learn from failure, and – perhaps most importantly – have a little patience.

Global Health Fellows Program: HIV/AIDS Testing and Counseling Intern

Introduction: The HIV/AIDS Testing and Counseling Intern will be assigned to the Technical Leadership and Research Division in the Bureau for Global Health’s Office of HIV/AIDS. The Office of HIV/AIDS is the focus of HIV/AIDS technical leadership for USAID and has primary responsibility for leading the Agency’s efforts within President’s Emergency Plan for AIDS Relief (PEPFAR), a multibillion dollar, multifaceted approach to combating the disease in more than 120 countries around the world. In cooperation with the US Department of State’s Office of the US Global AIDS Coordinator, other US Government (USG) partners, international organizations, and nongovernmental organizations, USAID provides global technical leadership on the full range of issues related to HIV/AIDS prevention, care, and treatment; manages numerous research and field support programs; and monitors the impact of the Agency’s HIV/AIDS programs. In this endeavor, USAID works very closely with a range of USG agencies involved in the fight against AIDS, such as the US Centers for Disease Control and Prevention, Department of Defense, and Peace Corps. More information about PEPFAR may be found here.

The intern will serve primarily as a research analyst/assistant, but may also carry out other Global Health Bureau-wide duties and collaborative research with other analysts in the Bureau. S/he will focus on the area of HIV testing and counseling. S/he will be managed by the HIV Testing and Counseling Advisor and will work closely with the entire Technical Leadership and Research Division. Information on USAID’s work in HIV testing and counseling can be found here.

Learning Objectives: To gain a greater understanding of USAID, PEPFAR and international work being done in the area of HIV/AIDS, and to gain knowledge and expertise within the broader area of HIV testing and counseling.

Specific Activities

  1. Assist in the development and rollout of various PEPFAR-supported interagency projects focusing on HIV testing and counseling
  2. Prepare literature reviews and other analytical work as requested
  3. Participate in dialogues with WHO and other multilateral partners involved in HIV testing and counseling work
  4. Participate in technical assistance with the field, including potentially one trip to the field
  5. Attend program-related events within and outside USAID as requested
  6. If appropriate, international travel to support USAID Missions may be required

Qualifications: The applicant will be enrolled in a graduate program related to public health, international development, or a related field. Qualified candidates will have strong writing and analytic skills, and experience in research and analysis.

To apply, please go to the Internship Recruitment Portal at www.ghfp.net.  NOTE: Resumes and CVs not submitted via the portal will NOT be reviewed by the selection committee.  If you have any questions or comments, please feel free to contact us at ghfpinternship@ghfp.net.

Global Health News Last Week

SECTION NEWS

APHA’s 2011 Section elections are coming up soon! Online voting will open on May 16 and ends on June 20. Section members should receive an e-mail on May 16 (next Monday) which will include:

  • Your online election validation number
  • Your APHA membership ID number
  • Voting instructions
  • A direct link to your voting Web site

All you have to do is click on the direct link and VOTE!

APHA’s Trade and Health Forum has released its first newsletter! The Forum has established a quarterly APHA Trade & Health Forum Newsletter that includes brief reports from forum members regarding recent work and analyses of issues related to trade and health, as well as announcements for trade and health advocacy opportunities and events. The first spring issue can be viewed here (PDF).


David Sencer, the longest-serving director of the U.S. Centers for Disease Control and Prevention (CDC) and one of the leaders of the U.S. contribution to the smallpox campaign, passed away at age 86 on May 2.

May 5 was International Day of the Midwife.

POLICY

  • The Association of Southeast Asian Nations (ASEAN) and the World Health Organization (WHO) have joined forces to assist Asia Pacific countries in identifying priority actions for dengue prevention and control.
  • On May 11, dozens of countries around the world will kick off the first global Decade of Action for Road Safety, from 2011-2020.
  • Starting last week, China’s Ministry of Health is strengthening its tobacco rules to require 28 types of businesses, including bars, coffee shops, hotels and stadiums to become 100 percent smoke-free.

PROGRAMS

  • After a sensationalistic (and rather silly) report from the AP on corruption and graft, the Global Fund has assembled a high-level panel of independent experts to assess the risk of fraud in the current portfolio. The review should be concluded by mid-September
  • Sri Lanka commemorated 100 years of its National Malaria Control Program, which has brought the death toll from malaria from 80,000 per year to 0, on May 5. In 2010, only 684 cases of malaria were reported in the country.
  • Health officials in India have taken up a pilot project at taluka places to identify areas with less number of institutional deliveries to bring down maternal deaths.
  • UNICEF has found that boreholes drilled in response to the Zimbabwe cholera outbreak in 2008 have not been adequately supported by the government in Harare.
  • USAID announced that it will be launching a $10 million mobile health program which will deliver information and tips to mothers via SMS.

RESEARCH

  • Protease inhibitors used to treat patients with HIV looks to provide an effective treatment to malaria as well and are being hailed as ‘superdrugs.’
  • Headaches are the most common health disorders across the world, yet they remain neglected and under-treated, according to a UN study.
  • Researchers warn that East African plants that could cure malaria could disappear before scientists have a chance to study them.

DISEASES AND DISASTERS

Thanks, as usual, to the Healthy Dose and Humanosphere.

The Greatest Thing You’ll Ever Learn: Drug-Resistant Tuberculosis on the Rise

On most days, tuberculosis only crosses the average American’s awareness radar when he or she is watching Moulin Rouge! for the fifth time. Even then, the sight of the courtesan Satine (played by Nicole Kidman) coughing up blood after singing about diamonds gives the impression that TB is the problem of sex workers living in elephants in 19th-century France. All of this changed in 2007, when Georgia lawyer Andrew Speaker snuck back into the U.S. through Canada after honeymooning in Europe – and being diagnosed with extensively-drug-resistant tuberculosis (XDR-TB).

As if regular TB were not bad enough, global health professionals are now grappling with the rising incidence of multi-drug-resistant (MDR-TB) and extensively-drug-resistant (XDR-TB) tuberculosis. MDR-TB is resistant at least to isoniazid and rifampicin, the two most powerful first-line antibiotics used to treat TB. It typically develops when patients being treated for fully sensitive TB stop their treatment course or do not follow it regularly (either because they feel better or forget to take their drugs, or because treatment supplies run out). When the treatment is interrupted before all of the bacteria are killed, the microbes develop resistance to the drugs. XDR-TB has all of this and more: it is also resistant to any fluoroquinolone and at least one of three injectable second-line drugs (capreomycin, kanamycin, and amikacin). If these drugs sound scary, it is because they are: most second-line drugs are less effective than isoniazid and rifampicin and can be moderately to highly toxic.

While the incidence of drug-resistant strains of TB is low for the moment, it is on the rise: a recent report by the WHO found that over two million people will contract some form of drug-resistant TB by 2015. The frequency of these infections is increasing fastest in India, China, and the former USSR. The WHO is asking countries to put their money where their mouths are and step up to fight the disease. “Commitments by some countries are too slow off the mark or simply stalled,” said Rifat Atun, director of strategy, performance and evaluation at the Global Fund. In the meantime, the greatest thing you’ll ever learn…is to finish your antibiotic course.